Teen Depression’s Immune Signature refers to the pattern of changes seen in the immune system of adolescents who experience depression. Research shows that depression in teenagers is not only a mental health condition—it is often linked with measurable immune and inflammatory changes in the body.
In simple terms:
What happens in the brain?
Depression affects brain chemicals involved in mood, sleep, and motivation (like serotonin and dopamine).
What happens in the immune system?
Many depressed teens show higher levels of inflammatory markers in their blood, such as:
Cytokines (e.g., IL-6, TNF-α)
C-reactive protein (CRP)
These are chemicals normally released when the body fights infection or stress.
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